Gharib Fawi Mohamed1, Taher Abd El-Raheem1, Nayel Abd El-Hamed Zaky2, Mohammed Abdal Abbas1, Islam Gad Elrap Ahmed1,

1Department of neuropsychiatry, Sohag University, Sohag, Egypt 2Department of internal medicine, Sohag University, Sohag, Egypt

Background: peripheral Neuropathy (PN) is a well-known complication of chronic renal failure (CRF). The frequency of PN in patients with CRF has declined owing to improvement in the modalities and techniques of dialysis and uremic neuropathy can be considered as an indicator of inadequate treatment by dialysis Aim of the work: is to quantitively determine the electrophysiological changes in both peripheral and central nervous system in CRF and to determine the differences between CRF patients on dialysis and
those who don’t start dialysis yet regarding neuropathy and cognitive impairment.
Materials and Methodology: we studied two groups of patients from the dialysis unit in Sohag faculty medicine, in addition to a control group. Group I is patients with CRF, who recently diagnosed and where the decision of dialysis was taken (10 pts). Group II is on dialysis for more than one year (10 pts). All
patients were subjected to full clinical assessment relevant to the peripheral neuropathy, laboratory evaluation, abdominal ultrasonography, nerve conduction studies, electromyography, mini-mental state examination and P30
Neuropathy is found in 75% of patients. NCS show that both motor and sensory fibers were affected and both axonal degeneration and demyelination were present. Neurophysiological abnormalities and cognitive impairment in group Ι were more than at group II
This study clearly demonstrated that neuropathy is very common in CRF patients and neurophysiological abnormalities in group Ι were more common than in group ΙΙ. This show the importance of hemodialysis in reduction of uremic neuropathy and its sensory symptoms